What do driver mutations do

Great talk today by Angelika Amon on aneuploudy and very interesting ideas about its potential impact on chromosomal instability and treatment resistance. Do we need to start looking at mutations differently?

The tumor environment and the tempo of somatic evolution

Our latest work looking at the pace of evolution and the role of the tumor's environment in driving that pace. We use an agent-based model and data from glioblastoma patients to show that certain microenvironments (at least in GBM) change the birth/death dynamics in hierarchically-organized tissues so that different sections of a tumor could have different paces of evolution

March for science 2018

Many of us in the Tampa Bay area (but certainly not as many as I was hoping) attended the 2018 edition of the march for science. As I wrote last year for the first edition of the march, we scientists need to be more involved in explaining to others what we do and why it has value.