Cancer ecology · evolution · therapy

Evolution shapes cancer. We use it to rethink treatment.

The CancerEvo Group combines mathematical modeling with experimental cancer biology to understand treatment resistance and help design more durable therapies.

Members of the CancerEvo Group together at Moffitt Cancer Center
The CancerEvo Group at Moffitt Cancer Center

What we investigate

Cancer as an evolving ecosystem

Tumors are heterogeneous populations under selection. Treatment changes that selection—and the evolutionary paths available to cancer cells.

Tumor heterogeneity

We study how diversity within tumors influences progression, adaptation, and response to therapy.

Evolutionary dynamics

We model how cancer cell populations respond to treatment and to their ecological context.

Treatment resistance

We seek evolution-informed strategies that anticipate resistance rather than only reacting to it.

Our approach

Models become most useful when they are developed in close dialogue with experiments and clinically meaningful questions.