Based at the Moffitt Cancer Center, Florida, Cancer Ecology is a small research group led by David Basanta. We are mathematical modellers who work with biologists and clinicians, trying to understand the ecology of tumors and the evolutionary dynamics of cancer progression and resistance to treatment.

Etienne at the AACR

Etienne at the AACR

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If you are attending AACR, please come and check Etienne and his poster. In it, he describes our work trying to better understand the bone ecosystem. Specifically the role of macrophages during bone injury repair. Macrophages are very interesting cells that can perform a wide variety of tasks following microenvironmental cues: they polarize into different phenotypes that allow them to take away debris and help with healing. There are many reasons why this is relevant in bone metastatic cancer but given how little we know about how they work in the bone, we have spent a fair amount of time building and biologically educating and challenging the model. So if you are around, do come and talk to Etienne.

What do driver mutations do

What do driver mutations do

The tumor environment and the tempo of somatic evolution

The tumor environment and the tempo of somatic evolution