Based at the Moffitt Cancer Center, Florida, Cancer Ecology is a small research group led by David Basanta. We are mathematical modellers who work with biologists and clinicians, trying to understand the ecology of tumors and the evolutionary dynamics of cancer progression and resistance to treatment.

Online introduction to computational oncology

I have recently found an interesting introduction to computational oncology on the website of Paul Macklin, a graduate student at UC Irvine.

The website comes complete with the stages of cancer evolution (not the usual 6 capabilities of Hanahan & Weinberg but a version a little bit coarse grained for my taste) and therapies. He also points out some of the challenges that need to be addressed such as explicitly incorporating the tumour microenvironment (it is a well known fact that some tumour cells behave like regular healthy cells if left in a different microenvironment from the one it comes from). Useful for people who might want to understand some of the aim of the papers I mention in my reviews.

Edge of existence

Merlo et al: Cancer as an evolutionary and ecological process.